Some games are best played horizontally, some others vertically.

Some keysets need to be redefined. (eg: in some vertical shoot'em ups, it's convenient to have the single fire button also launch land missiles)

Some games require overclocking, some will also work UNDERclocked. (Thus saving Wiz batteries, which will last longer.)

If you don't have the patience to set them up one by one yourself, you might want to try out my settings.